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The unique mineral profile and osmotic properties of hyperthermal water from the Euganean Thermal area of Italy have been used for thousands of years as a natural, traditional therapy. Hyperthermal Salso-Bromo-Iodic water from deep geothermal wells has a unique mineral signature obtained over decades of circulation in rock strata up to 4 kilometers deep and at temperatures up to 170 °C.

Thermalis has a long history of developing hyperthermal water based therapies including Thermalis Therapeutic Biomud (Biofango) and Physiorex massage cream as adjunctive therapy for inflammatory conditions and muscle aches and pains, and Thermalis hyperthermal water nasal spray.